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With a minimum temperature of 5 °C (41 °F), dieffenbachia must be grown indoors in temperate areas. They need light, but filtered sunlight through a window is usually sufficient. They also need moderately moist soil, which should be regularly fertilized with an appropriate houseplant fertilizer.

Dieffenbachia prefer medium sunlight, moderately dry soil and average home temperatures of 62–80 F Most require water about twice a week.